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Pharmacotherapeutic group: Rhinologics. ATC code: R01AA07.
Pharmacology: Pharmacodynamics: Xylometazoline, an imidazole derivative, is an alpha-adrenergic sympathomimetic drug. Its vasoconstrictor action produces mucosal decongestion. Onset of action is usually within 5-10 minutes, facilitating nasal breathing by mucosal decongestion and improving drainage of secretions.
Pharmacokinetics: The effect of xylometazoline sets in within a few minutes and remains for several hours (on the average 6-8 h).
The amount of drug absorbed following intranasal application may occasionally be large enough to produce systemic effects, e.g. on the central nervous and cardiovascular systems.
No data from pharmacokinetic studies in humans are available.
